Papillon CXB in the United States

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Papillon CXB in the United States
Redefining Rectal Cancer Care in North America

Interest in Papillon Contact X-ray Brachytherapy (CXB) is experiencing a strong resurgence across North America, driven by emerging clinical evidence and increased focus on organ-preserving treatment approaches.

Recent randomised clinical trials, including the OPERA Trial, have played a key role in reshaping clinical perspectives. Alongside this, guidance from the National Institute for Health and Care Excellence (NICE) in the UK has further reinforced confidence in Papillon CXB as a viable non-surgical option for selected rectal cancer patients.

While Contact X-ray Brachytherapy was first developed in the mid-20th century, its adoption was historically limited by the rise of conventional surgical approaches. Today, advances in technology and clinical understanding have positioned Papillon CXB as a sophisticated, non-invasive alternative—supporting organ preservation, improving patient quality of life, and offering favourable long-term healthcare economics.

Clinical trials and evaluation programmes are now underway at several leading centres of excellence across North America. Ariane Medical Systems is proud to collaborate with these institutions and looks forward to supporting the transition from clinical evaluation to broader implementation.

For further information, please contact:

Mark Davies-Cousins
VP International Sales
📞 +44 (0) 7940 359998
✉️ mark.davies@arianemedicalsystems.com

First Patient Treatments Delivered at New Centre of Excellence – St Bartholomew’s Hospital, London

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St Bartholomew’s Hospital has successfully delivered its first Papillon Contact X-ray Brachytherapy (CXB) patient treatments, marking a significant milestone in expanding access to this specialist therapy in the UK.

The first patients were treated onsite on 16th January 2026, enabling individuals with lower rectal cancer to access treatment within London for the first time, removing the need to travel to centres such as Liverpool or Hull.

The treatments were supported by Arthur Sun Myint from the Clatterbridge Cancer Centre, who worked alongside Pablo Neclares and the St Bartholomew’s clinical team to deliver the procedures.

While Papillon CXB has been available in the UK for nearly 30 years, with four established sites across England since 2014 and over 5,000 patients treated, St Bartholomew’s Hospital is the first centre in London to offer this technology, and the first new UK site to be introduced since 2014.

Following recent guidance from the National Institute for Health and Care Excellence (NICE) recommending Papillon CXB as a non-surgical treatment option for selected patients, interest in the technology has increased significantly both across the UK and internationally.

This milestone represents an important step forward in improving patient access to organ-preserving, non-invasive treatment options within the capital.

Papillon CXB Clinical Engagement Across India & Sri Lanka

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Papillon CXB Clinical Engagement Across India & Sri Lanka

Mark Davies-Cousins – VP International Sales

Mark Davies-Cousins, VP International Sales at Ariane Medical Systems, recently completed an extensive clinical knowledge-sharing initiative across India and Sri Lanka, delivered between 29th January and 12th February 2026.

The programme formed part of Ariane’s ongoing commitment to supporting clinical education, strengthening partnerships, and expanding access to Papillon Contact X-ray Brachytherapy (CXB) technology across key international markets.

The visit began with participation in the Medical Fair India 2026 in New Delhi, before continuing with a series of clinical engagements across leading healthcare institutions.

India & Sri Lanka Itinerary 2026

10th – 12th February | Colombo, Sri Lanka

29th – 31st January | New Delhi
Medical Fair India – Bharat Mandapam (Pragati Maidan)

1st – 3rd February | Mumbai
Tata Memorial Hospital, Tata Cancer Care Foundation, Asian Cancer Institute,
HN Reliance Hospital, Hinduja Hospital

4th February | Hyderabad
Yashoda Hospitals, Omega Hospitals, AIG Hospitals

5th – 7th February | Chennai
Apollo Hospitals, Cancer Institute Chennai, MIOT International Hospital,
Christian Medical College (Vellore), AROI

9th February | Trivandrum
Regional Cancer Centre

Across all locations, the initiative provided valuable opportunities to present Papillon CXB technology, discuss clinical applications, and engage directly with multidisciplinary teams, including radiation oncologists, surgeons, and medical physicists.

This programme highlights the growing international interest in non-invasive treatment approaches and reinforces Ariane Medical Systems’ commitment to supporting the global adoption of Papillon technology.

New Commercial Partnership Established in India

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New Commercial Partnership Established in India
Ariane Medical Systems in Mumbai

Ariane Medical Systems is pleased to announce a new commercial partnership in India, working alongside Venkatesan KS from Leo Medical.

During a recent visit to Mumbai, Mark Davies-Cousins met with the team to strengthen collaboration and support the introduction of Papillon technology within the region.

The visit also included a detailed clinical presentation on Papillon Contact X-ray Brachytherapy (CXB) at Tata Memorial Hospital, one of India’s leading cancer institutions.

The session was attended by Ashwin D’Souza and Reena Engineer, alongside members of the surgical team and medical students, reflecting strong clinical interest in the technology.

This partnership marks an important step in expanding access to Papillon CXB and supporting the continued development of non-invasive treatment options within international healthcare settings.

Forthcoming Events

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Forthcoming Events
2026 Diary Dates

We look forward to attending and engaging with the global clinical community at the following events in 2026

ESTRO 2026
15th – 19th May 2026 | Stockholm, Sweden

American Brachytherapy Society Annual Meeting 2026
17th – 20th June 2026 | Los Angeles, CA, USA

ESTRO Asia 2026
28th – 30th August 2026 | Singapore

ESSO 45
4th – 6th November 2026 | Madrid, Spain

GEC-ESTRO 2026
19th – 20th November 2026 | Seville, Spain

Clatterbridge Papillon+ Training Conference Successfully Delivered

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25-26th March 2026
Clatterbridge Papillon+ Training Conference Successfully Delivered

The first of two Papillon+ training conferences scheduled for 2026 was successfully delivered on 25th–26th March, bringing together clinicians from across the UK and North America.

Hosted by Arthur Sun Myint and Jean Pierre Gérard, the two-day event provided a structured programme focused on clinical practice, collaboration, and knowledge sharing.

Attendees benefited from a range of expert-led sessions, alongside valuable discussions around the continued development and application of Papillon+ technology in clinical settings.

The event highlighted the growing international interest in non-invasive treatment approaches and reinforced the importance of shared learning in advancing patient care.

Leading Advocate of Papillon Technology Presents at HSJ Cancer Forum

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13th March 2026

Arthur Sun Myint, one of the leading advocates of Papillon technology, recently presented at the HSJ Cancer Forum, contributing to discussions on the progression of innovation into everyday clinical practice.

Drawing on decades of experience in the development and application of Papillon therapy, Professor Myint shared insights on how advancements in treatment are translating into real-world benefits for patients. His presentation highlighted the importance of bridging the gap between early-stage innovation and widespread clinical adoption.

The session reinforced the growing role of non-invasive treatment options in cancer care and the importance of continued collaboration across the healthcare sector to support improved patient outcomes.

🔗 Read the full article here:
https://www.linkedin.com/pulse/from-innovation-pilots-practice-professor-arthur-sun-myintobpse

Clatterbridge Cancer Centre Papillon+ Training a Strong Success

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28th March 2026
Clatterbridge Cancer Centre Papillon+ Training a Strong Success
The Liner Hotel, Liverpool | 25th–26th March 2026

The first of two Papillon+ training events scheduled for 2026 was successfully delivered at The Liner Hotel, hosted by Arthur Sun Myint and Jean Pierre Gérard.

The two-day event welcomed clinicians and specialists from across Great Britain and North America, reflecting the growing international interest in Papillon+ technology.

Momentum has continued to build following the National Institute for Health and Care Excellence (NICE) approval on 13th November 2025. NICE now recommends Contact X-ray Brachytherapy (CXB) for selected lower rectal cancer patients, including operable cases with tumours up to T3a–b. These updated guidelines represent a significant step forward, offering more patients the opportunity for organ preservation and non-invasive treatment options.

A key focus of the training was the OPERA Trial, alongside wider discussion on the evolving “watch and wait” approach in rectal cancer management.

The event also benefited from multidisciplinary input, with valuable contributions from surgical teams, radiation oncology specialists, and medical physics professionals.

With both clinical outcomes and healthcare economics under increasing scrutiny, Papillon+ is continuing to establish itself as a credible alternative to conventional surgery—particularly in improving post-treatment quality of life.

Following NICE approval, momentum in the UK continues to accelerate. Several clinical trials are now in the pipeline, with an additional 8–10 installations expected across treatment centres of excellence by the end of 2026.

Ariane Medical Systems at ESTRO Stockholm 2026

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14th April 2026
Ariane Medical Systems at ESTRO Stockholm 2026
15th – 19th May | Stand C03:43

Ariane Medical Systems will showcase its Papillon+ technology at ESTRO 2026 in Stockholm this May.

Join us at Stand C03:43 to explore how Papillon+ is advancing clinical practice and improving patient outcomes.

Our team will be on hand throughout the event to discuss the technology, answer questions, and share insights from across the field.

For those who would like a dedicated conversation, appointments can be arranged with:

Mark Davies-Cousins
VP International Sales
📞 +44 (0) 7940 359998
✉️ mark.davies@arianemedicalsystems.com

Alternatively, feel free to visit us at the stand at any time during the event — we would be delighted to welcome you.

🌐 www.arianemedicalsystems.com

LEO HEALTHCARE at MAGIC 2026

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18th April 2026
LEO Healthcare at MAGIC 2026
Venkatesan KS Representing Papillon+

From our man in the field…

MAGIC 2026 proved to be a highly valuable and well-executed event, bringing together leading voices across clinical practice.

Representing Papillon+, Venkatesan KS had the opportunity to engage with a wide range of delegates, contributing to insightful discussions and meaningful exchanges throughout the conference.

The quality of the academic sessions stood out, offering practical insights and reinforcing the importance of collaboration in advancing patient care.

Events like MAGIC continue to play a vital role in connecting professionals, sharing knowledge, and strengthening partnerships across the industry.

A sincere thank you to the organisers for delivering such a seamless and impactful event. We look forward to continuing these conversations and building on the connections made.

BR
Venkatesan KS